Version: 8.0.0Date: Tue Jan 28 2025
Gene
Pten
- Species
- Mus musculus
- Symbol
- Pten
- Name
- phosphatase and tensin homolog
- Synonyms
- 2310035O07Rik
- A130070J02Rik
- Biotype
- protein coding gene
- Automated Description
- Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein kinase binding activity; and ubiquitin ligase activator activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of leukocyte apoptotic process; and regulation of signal transduction. Located in several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and nucleus. Is active in neuron projection. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and sensory organ. Used to study several diseases, including Cowden syndrome (multiple); carcinoma (multiple); macrocephaly-autism syndrome; persistent fetal circulation syndrome; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); macrocephaly-autism syndrome; nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
- MGI Description
- PHENOTYPE: Homozygous null mutants die by E9.5 with abnormally patterned enlarged brains and defective placentas. Heterozygotes develop a range of neoplasms. Conditional mutants demonstrate effects on basic processes of proliferation, differentiation and apoptosis. KO of the alpha isoform affects mitophagy and causes olfactory, spatial learning and contextual fear memory deficits and increases susceptibility to induced cardiac injury. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12305
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr19:32734977...32803560 + (68.58 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.