Gene

Aip

Species
Mus musculus
Symbol
Aip
Name
aryl-hydrocarbon receptor-interacting protein
Synonyms
  • AA408703
  • Ara9
Biotype
protein coding gene
Automated Description
Enables aryl hydrocarbon receptor binding activity and transcription coregulator activity. Acts upstream of or within xenobiotic metabolic process. Located in cytosol and membrane. Part of aryl hydrocarbon receptor complex. Is expressed in several structures, including liver; nervous system; ovary; retina; and urinary system. Human ortholog(s) of this gene implicated in pituitary adenoma 1. Orthologous to human AIP (aryl hydrocarbon receptor interacting protein).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in lethality from E10 to E19. Mice exhibit cardiac malformations such as double outlet right ventricle and ventricular septal defect and sometimes hemorrhage or petechiae. Mice homozygous for a hypomorphic allele exhibit patent ductus venosus. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11242
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
4.166M4.168M4.170M4.172M4.174M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions