Enables aryl hydrocarbon receptor binding activity and transcription coregulator activity. Acts upstream of or within xenobiotic metabolic process. Located in cytosol and membrane. Part of aryl hydrocarbon receptor complex. Is expressed in several structures, including liver; nervous system; ovary; retina; and urinary system. Human ortholog(s) of this gene implicated in pituitary adenoma 1. Orthologous to human AIP (aryl hydrocarbon receptor interacting protein).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in lethality from E10 to E19. Mice exhibit cardiac malformations such as double outlet right ventricle and ventricular septal defect and sometimes hemorrhage or petechiae. Mice homozygous for a hypomorphic allele exhibit patent ductus venosus. [provided by MGI curators]