Enables GTPase activity. Involved in several processes, including alpha-beta T cell differentiation; negative regulation of metabolic process; and regulation of cytoskeleton organization. Acts upstream of or within several processes, including nervous system development; positive regulation of organelle organization; and regulation of systemic arterial blood pressure by hormone. Located in several cellular components, including cytosol; lamellipodium; and ruffle membrane. Is expressed in several structures, including exocrine system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A).
MGI Description
PHENOTYPE: Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube. [provided by MGI curators]