Gene

Rhoa

Species
Mus musculus
Symbol
Rhoa
Name
ras homolog family member A
Synonyms
  • aplysia ras homolog A
  • Arha
Biotype
protein coding gene
Automated Description
Enables GTPase activity. Involved in several processes, including alpha-beta T cell differentiation; negative regulation of metabolic process; and regulation of cytoskeleton organization. Acts upstream of or within several processes, including nervous system development; positive regulation of organelle organization; and regulation of systemic arterial blood pressure by hormone. Located in several cellular components, including cytosol; lamellipodium; and ruffle membrane. Is expressed in several structures, including exocrine system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A).
MGI Description
PHENOTYPE: Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24072
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
108.185M108.190M108.195M108.200M108.205M108.210M108.215M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions