Version: 8.0.0
Date: Tue Jan 28 2025
Cyp26a1
Mus musculusMGI:1096359
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cyp26a1

Species
Mus musculus
Symbol
Cyp26a1
Name
cytochrome P450, family 26, subfamily a, polypeptide 1
Synonyms
  • Cyp26
  • cytochrome P450, 26, retinoic acid
Biotype
protein coding gene
Automated Description
Enables retinoic acid 4-hydroxylase activity. Involved in cellular response to retinoic acid and retinoic acid catabolic process. Acts upstream of or within anterior/posterior pattern specification; central nervous system development; and neural crest cell development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and sensory organ. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations die during mid-late gestation and exhibit spina bifida, caudal agenesis, and abnormalities of the kidneys, urogenital tract, hindgut, cervical vertebrae, and rostral hindbrain. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24286
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            37.6865M37.6870M37.6875M37.6880M37.6885M37.6890M37.6895M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Cyp26a1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Cyp26a1 role
              Cyp26a1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
              Source
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