Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neuromuscular synaptic transmission; regulation of branching involved in mammary gland duct morphogenesis; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study T-cell adult acute lymphocytic leukemia. Orthologous to human ETV5 (ETS variant transcription factor 5).
MGI Description
PHENOTYPE: Homozygous null mice display either male infertility, small testes, azoospermia, and failure to maintain spermatogonia or they are prenatally lethal. Preaxial polydactyly has also been observed. [provided by MGI curators]