Gene

Nrg3

Species
Mus musculus
Symbol
Nrg3
Name
neuregulin 3
Synonyms
  • scaramanga
  • ska
Biotype
protein coding gene
Automated Description
Enables chemorepellent activity. Involved in ERBB4-ERBB4 signaling pathway and synapse assembly. Acts upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Is active in extracellular space and glutamatergic synapse. Is expressed in several structures, including embryo mesenchyme; epidermis; mammary gland primordium; nervous system; and testis. Used to study schizophrenia. Orthologous to human NRG3 (neuregulin 3).
MGI Description
PHENOTYPE: Mutations in this gene result in abnormal, genetic background specific, mammary gland development. Male mice homozygous for a knock-out allele show novelty-induced hyperactivity, decreased prepulse inhibition, and impaired cued conditioning behavior. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11100
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
38.1M38.2M38.3M38.4M38.5M38.6M38.7M38.8M38.9M39.0M39.1M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions