Gene

Suv39h1

Species
Mus musculus
Symbol
Suv39h1
Name
suppressor of variegation 3-9 1
Synonyms
  • AI852103
  • AL022883
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and histone H3K9me2 methyltransferase activity. Involved in circadian rhythm; negative regulation of DNA-templated transcription; and negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including blastocyst hatching; determination of adult lifespan; and regulation of bone mineralization. Located in heterochromatin and nucleus. Part of chromatin silencing complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase).
MGI Description
PHENOTYPE: About one third of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46223
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            7.928M7.930M7.932M7.934M7.936M7.938M7.940M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Suv39h1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Suv39h1 role
              Suv39h1 genetic perturbation
              Interactor gene
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