Gene

Synpo

Species
Mus musculus
Symbol
Synpo
Name
synaptopodin
Synonyms
  • 9030217H17Rik
  • 9330140I15Rik
Biotype
protein coding gene
Automated Description
Enables actin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of actin filament bundle assembly; and regulation of postsynaptic cytosolic calcium ion concentration. Located in cell periphery and stress fiber. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including genitourinary system; respiratory system; sensory organ; skeleton; and tooth. Orthologous to human SYNPO (synaptopodin).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this gene display abnormalities in telencephalic neurons, reduced long term potentiation, and behavioral abnormalities including hypoactivity, reduced anxiety, and learning deficiencies. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24217
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            60.73M60.74M60.75M60.76M60.77M60.78M60.79M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Synpo molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Synpo role
              Synpo genetic perturbation
              Interactor gene
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