Gene

Flot1

Species
Mus musculus
Symbol
Flot1
Name
flotillin 1
Synonyms
  • Rareg
  • reggie-2
Biotype
protein coding gene
Automated Description
Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cellular component organization; and positive regulation of dopaminergic synaptic transmission. Acts upstream of or within axonogenesis and regulation of Rho protein signal transduction. Located in caveola; external side of plasma membrane; and sarcolemma. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FLOT1 (flotillin 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil recruitment. Homozygous double KO with Flot2 increases susceptibility to induced necroptosis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13806
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
36.135M36.136M36.137M36.138M36.139M36.140M36.141M36.142M36.143M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions