Enables mRNA 3'-UTR binding activity and pre-mRNA binding activity. Involved in circadian regulation of translation; entrainment of circadian clock by photoperiod; and regulation of nucleocytoplasmic transport. Acts upstream of or within several processes, including insulin secretion involved in cellular response to glucose stimulus; regulation of gene expression; and regulation of insulin receptor signaling pathway. Located in nucleolus and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human RBM4 (RNA binding motif protein 4).
MGI Description
PHENOTYPE: Mice homozygous for a null mutation display reduced postnatal body weight, decreased insulin levels, smaller pancreatic islets and impaired glucose tolerance. [provided by MGI curators]