Version: 8.0.0
Date: Tue Jan 28 2025
Asic2
Mus musculusMGI:1100867
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Asic2

Species
Mus musculus
Symbol
Asic2
Name
acid-sensing ion channel 2
Synonyms
  • Accn1
  • amiloride-sensitive cation channel 1, neuronal (degenerin)
Biotype
protein coding gene
Automated Description
Enables ligand-gated sodium channel activity and monoatomic ion-gated channel activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; and sensory perception of mechanical stimulus. Located in dendritic spine; neuronal cell body; and plasma membrane. Is active in postsynaptic density membrane. Is expressed in several structures, including central nervous system. Orthologous to human ASIC2 (acid sensing ion channel subunit 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased mechanoreceptor and spiral ganglion electrophysiology and decreased pressure-induced blood vessel constriction. Mice homozygous for a different knock-out allele exhibit retinal degeneration and abnormal eye electrophysiology. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11690
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Asic2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Asic2 role
            Asic2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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