Version: 8.0.0
Date: Tue Jan 28 2025
Kcnj10
Mus musculusMGI:1194504
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kcnj10

Species
Mus musculus
Symbol
Kcnj10
Name
potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms
  • BIR10
  • BIRK-1
Biotype
protein coding gene
Automated Description
Enables inward rectifier potassium channel activity. Involved in cellular response to potassium ion and non-motile cilium assembly. Acts upstream of or within several processes, including adult walking behavior; glutamate reuptake; and regulation of resting membrane potential. Located in astrocyte projection; basolateral plasma membrane; and cell body. Is active in ciliary base. Is expressed in several structures, including brain; cochlea; genitourinary system; spinal cord; and stomach. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10).
MGI Description
PHENOTYPE: Homozygous mutant mice show increased input resistance and high depolarization of retinal Muller cells, loss of the endocochlear potential, motor coordination deficits and hindlimb paralysis, and a hypomyelination and spongiform vacuolation in the spinalcord associated with severe axonal pathology. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11767
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            172.170M172.175M172.180M172.185M172.190M172.195M172.200M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Kcnj10 molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              Kcnj10 role
              Kcnj10 genetic perturbation
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