Version: 8.0.0
Date: Tue Jan 28 2025
Fxyd2
Mus musculusMGI:1195260
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fxyd2

Species
Mus musculus
Symbol
Fxyd2
Name
FXYD domain-containing ion transport regulator 2
Synonyms
  • ATP1C
  • Atp1g1
Biotype
protein coding gene
Automated Description
Enables sodium channel regulator activity. Acts upstream of or within regulation of sodium ion transmembrane transporter activity. Located in membrane. Is expressed in several structures, including early conceptus; gonad; intestine smooth muscle circular layer; metanephros; and spleen. Human ortholog(s) of this gene implicated in renal hypomagnesemia 2. Orthologous to human FXYD2 (FXYD domain containing ion transport regulator 2).
MGI Description
PHENOTYPE: Homozygous null mice are viable and fertile but display abnormal renal NaK-ATPase kinetics. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14132
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Fxyd2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Fxyd2 role
            Fxyd2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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