Version: 8.0.0
Date: Tue Jan 28 2025
Tsc22d3
Mus musculusMGI:1196284
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Tsc22d3

Species
Mus musculus
Symbol
Tsc22d3
Name
TSC22 domain family, member 3
Synonyms
  • delta sleep inducing peptide, immunoreactor
  • Dsip1
Biotype
protein coding gene
Automated Description
Acts upstream of or within negative regulation of activation-induced cell death of T cells and response to osmotic stress. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; sensory organ; and viscerocranium. Orthologous to human TSC22D3 (TSC22 domain family member 3).
MGI Description
PHENOTYPE: Hemizygous null males show mild deficits in sodium handling, weight reduction, hyperinsulinemia, resistance to liver steatosis, and sterility associated with azoospermia, testis dysplasia, Leydig cell hyperplasia, male germ cell apoptosis, arrested meiosis, and high FSH and testosterone levels. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12348
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Tsc22d3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Tsc22d3 role
            Tsc22d3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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