Gene

Dnmt3b

Species
Mus musculus
Symbol
Dnmt3b
Name
DNA methyltransferase 3B
Synonyms
None
Biotype
protein coding gene
Automated Description
Enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA binding activity; and lncRNA binding activity. Involved in negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including cellular response to amino acid stimulus; epigenetic regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in chromosome, centromeric region; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system. Used to study immunodeficiency-centromeric instability-facial anomalies syndrome 1. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy 4; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation exhibit growth retardation and rostral neural tube defects, and die prenatally. Mutants exhibit slight under-methylation of endogenous viral DNA and substantial demethylation of minor satellite DNA. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23068
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
153.495M153.500M153.505M153.510M153.515M153.520M153.525M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions