Version: 8.0.0
Date: Tue Jan 28 2025
Atg5
Mus musculusMGI:1277186
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Atg5

Species
Mus musculus
Symbol
Atg5
Name
autophagy related 5
Synonyms
  • 2010107M05Rik
  • 3110067M24Rik
Biotype
protein coding gene
Automated Description
Predicted to contribute to Atg8-family ligase activity. Involved in several processes, including cellular response to nitrosative stress; macroautophagy; and negative regulation of defense response. Acts upstream of with a positive effect on chromatin organization. Acts upstream of or within several processes, including defense response to symbiont; negative regulation of cardiac muscle cell apoptotic process; and negative stranded viral RNA replication. Located in several cellular components, including autophagosome; mitochondria-associated endoplasmic reticulum membrane contact site; and phagophore assembly site membrane. Part of Atg12-Atg5-Atg16 complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in central nervous system; heart; lower jaw molar; and sensory organ. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5).
MGI Description
PHENOTYPE: Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, and have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutationin this gene show no abnormal phenotype. A kidney proximal tubular cell-specific KO allele exacerbates renal inflammation in mice subjected to unilateral ureteric obstruction. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13040
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Atg5 molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            Atg5 role
            Atg5 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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