Enables BMP binding activity; heparin binding activity; and proteoglycan binding activity. Involved in several processes, including cell surface receptor signaling pathway; circulatory system development; and modulation of chemical synaptic transmission. Acts upstream of or within several processes, including gastrulation; negative regulation of osteoblast differentiation; and osteoblast differentiation. Located in extracellular space. Is active in cell surface and extracellular region. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and skeletal system. Used to study DiGeorge syndrome and velocardiofacial syndrome. Orthologous to human CHRD (chordin).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation show some death prior to embryonic day 8.5, but most die perinatally with abnormalities of the skull, malformations of cervical and thoracic vertebrae, cardiovascular defects, and absence of parathyroid and thymus. [provided by MGI curators]