Gene

Vamp1

Species
Mus musculus
Symbol
Vamp1
Name
vesicle-associated membrane protein 1
Synonyms
  • lethal wasting
  • lew
Biotype
protein coding gene
Automated Description
Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in SNARE complex assembly; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in cell surface. Is active in glutamatergic synapse and neuromuscular junction. Is expressed in brain; cerebellum molecular layer; and ventral tegmental area. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1).
MGI Description
PHENOTYPE: Mice homozygous for a spontaneous mutation show a 30% reduction in body size, do not attempt to right themselves, become visibly immobile and lay on their side by postnatal day 10, and display a general lack of purposeful movement and wasting leading to death prior to weaning. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45701
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
125.193M125.194M125.195M125.196M125.197M125.198M125.199M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions