Enables all-trans-retinol dehydrogenase (NAD+) activity and all-trans-retinol dehydrogenase (NADP+) activity. Acts upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human DHRS3 (dehydrogenase/reductase 3).
MGI Description
PHENOTYPE: Mice homozygous for a targeted mutation die before weaning age. Mice homozygous for a gene trap allele exhibit perinatal lethality, altered retinoid metabolism and heart, craniofacial and skeletal defects. [provided by MGI curators]