Gene

Cacng2

Species
Mus musculus
Symbol
Cacng2
Name
calcium channel, voltage-dependent, gamma subunit 2
Synonyms
  • AW060990
  • B230105C07Rik
Biotype
protein coding gene
Automated Description
Enables voltage-gated calcium channel activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and postsynaptic neurotransmitter receptor diffusion trapping. Acts upstream of or within several processes, including membrane hyperpolarization; neuromuscular junction development; and transmission of nerve impulse. Located in somatodendritic compartment. Part of AMPA glutamate receptor complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Is expressed in several structures, including brain; genitourinary system; ileum; spinal cord; and trigeminal nerve. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2).
MGI Description
PHENOTYPE: Homozygotes for mutant alleles show growth retardation, movement anomalies including ataxic gait, tremor and head tossing, and neocortical spike-wave seizures. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12107
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            77.88M77.90M77.92M77.94M77.96M77.98M78.00M

            Sequence Details

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            Expression

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            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Cacng2 molecule type
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              Genetic Interactions

              Cacng2 role
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