Gene

Trex1

Species
Mus musculus
Symbol
Trex1
Name
three prime repair exonuclease 1
Synonyms
  • AU041952
  • expressed sequence AU041952
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in DNA metabolic process. Acts upstream of or within several processes, including DNA metabolic process; circulatory system development; and regulation of biosynthetic process. Located in cytosol; endoplasmic reticulum; and nuclear replication fork. Part of oligosaccharyltransferase complex and protein-DNA complex. Is expressed in lens. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1).
MGI Description
PHENOTYPE: Nullizygous mice display premature death, cardiomyopathy, myocarditis, atrial thrombosis, and altered spleen morphology. Homozygotes for the D18N allele develop lupus-like disease with systemic inflammation, lymphoid hyperplasia, vasculitis, production of autoantibodies to dsDNA, and renal disease. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13058
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            108.8870M108.8872M108.8874M108.8876M108.8878M108.8880M108.8882M108.8884M108.8886M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Trex1 molecule type
            Interactor gene
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              Genetic Interactions

              Trex1 role
              Trex1 genetic perturbation
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