Gene

Nts

Species
Mus musculus
Symbol
Nts
Name
neurotensin
Synonyms
  • 5033428E16Rik
  • neuromedin N
Biotype
protein coding gene
Automated Description
Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; neuropeptide signaling pathway; and visual learning. Predicted to be located in intracellular membrane-bounded organelle and neuronal cell body. Predicted to be active in axon terminus. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; jaw; and retina. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human NTS (neurotensin).
MGI Description
PHENOTYPE: Mice homozygous for a targeted null mutation are viable, fertile, and grossly normal, but display altered responses to antipsychotic drugs. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15356
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNTS10 of 10YesYes  
Rattus norvegicusNts9 of 9YesYes   
Xenopus tropicalisnts9 of 9YesYes   
Danio rerionts9 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal physiological response to xenobiotic
decreased body weight
decreased total body fat amount
Showing 1 - 3 of 3 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCm39
Viewer Help
102.318M102.319M102.320M102.321M102.322M102.323M102.324M102.325M102.326M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Ntstm1(flpo)Giml
  • NtsFlpO
allele
Ntsem1Gpt
  • Ntsem1Cflox
allele
Ntstm1(cre)Mgmj
  • NtsCre
allele
Yes
Ntsem1(icre)Smoc
  • Ntsem1(IRES-iCre)Smoc
allele
Ntsem1Evdr
  • Ntsflox
allele
Ntstm1Dob
  • NT-
allele
Yes
Ntsem2Smocallele
Ntstm1Mom
  • Neurotensin-IRES-tauGFP
  • NT-GFP
allele
NC_000076.7:g.102317923C>Tvariant
SNP
  • 3 prime UTR variant
NC_000076.7:g.102319557A>Tvariant
SNP
  • intron variant
Showing 1 - 10 of 262 rows
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Transgenic Alleles

No data available

Models

Showing 1 - 5 of 5 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
102.318M102.319M102.320M102.321M102.322M102.323M102.324M102.325M102.326MENSMUST00000020040 (Nts)NM_024435.2 (Nts)XM_006513992.4 (Nts)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available