Gene

S1pr4

Species
Mus musculus
Symbol
S1pr4
Name
sphingosine-1-phosphate receptor 4
Synonyms
  • Edg6
  • endothelial differentiation, G-protein-coupled receptor 6
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is active in presynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Orthologous to human S1PR4 (sphingosine-1-phosphate receptor 4).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in mid-gestation embryonic lethality. Heterozygotes exhibit decreased prepulse inhibition. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22750
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            81.3336M81.3338M81.3340M81.3342M81.3344M81.3346M81.3348M81.3350M81.3352M81.3354M81.3356M81.3358M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            S1pr4 molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              S1pr4 role
              S1pr4 genetic perturbation
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