Gene

Prkaa2

Species
Mus musculus
Symbol
Prkaa2
Name
protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms
  • 2310008I11Rik
  • Ampk
Biotype
protein coding gene
Automated Description
Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).
MGI Description
PHENOTYPE: Homozygous null mice are hyperglycemic, hypoinsulinemic, and show glucose intolerance and insulin resistance. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24343
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page

      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
      per page

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
        No records match query. Try removing filters.
        Showing 0 - 0 of 0 rows
        per page

          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
          No records match query. Try removing filters.
          Showing 0 - 0 of 0 rows
          per page

            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            104.89M104.90M104.91M104.92M104.93M104.94M104.95M104.96M

            Sequence Details

            Loading...

            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Prkaa2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
            No records match query. Try removing filters.
            Showing 0 - 0 of 0 rows
            per page

              Genetic Interactions

              Prkaa2 role
              Prkaa2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
              No records match query. Try removing filters.
              Showing 0 - 0 of 0 rows
              per page