Gene

Prkab2

Species
Mus musculus
Symbol
Prkab2
Name
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Synonyms
  • 5730553K21Rik
  • AW049591
Biotype
protein coding gene
Automated Description
Predicted to enable protein kinase binding activity. Predicted to contribute to AMP-activated protein kinase activity. Involved in positive regulation of cold-induced thermogenesis. Predicted to be located in apical plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; gallbladder; genitourinary system; and nervous system. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased exercise endurance, muscle force, muscle and liver glycogen, and skeletal muscle fiber size and increased susceptibility to diet induced obesity and hyperinsulinemia. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10343
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            97.566M97.568M97.570M97.572M97.574M97.576M97.578M97.580M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Prkab2 molecule type
            Interactor gene
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              Genetic Interactions

              Prkab2 role
              Prkab2 genetic perturbation
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