Version: 8.0.0
Date: Tue Jan 28 2025
Klhl22
Mus musculusMGI:1337995
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Klhl22

Species
Mus musculus
Symbol
Klhl22
Name
kelch-like 22
Synonyms
  • 2610318I18Rik
  • kelch-like (D. melanogaster)
Biotype
protein coding gene
Automated Description
Predicted to enable 14-3-3 protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including centrosome; intercellular bridge; and intracellular membrane-bounded organelle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol; mitotic spindle; and polar microtubule. Predicted to colocalize with lysosome and nucleus. Orthologous to human KLHL22 (kelch like family member 22).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit increased growth of implanted tumor cells with reduced survival and Cd4+ and CD8+ T cells expressing IFNgamma, TNF, and granzyme B. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45632
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Klhl22 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Klhl22 role
            Klhl22 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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