Predicted to enable RNA polymerase II core promoter sequence-specific DNA binding activity and RNA polymerase II general transcription initiation factor activity. Acts upstream of or within acrosome assembly; dTTP biosynthetic process; and spermatid nucleus differentiation. Located in cytoplasm and male germ cell nucleus. Part of transcription factor TFIIA complex. Is expressed in several structures, including central nervous system; early conceptus; ganglia; gonad; and sensory organ. Orthologous to human TBPL1 (TATA-box binding protein like 1).
MGI Description
PHENOTYPE: Males homozygous for targeted null mutations are sterile due to a block in spermiogenesis. Spermatids exhibit defective acrosome formation, fragmentation of the chromocenter, and develop at most to step 7 of differentiation. [provided by MGI curators]