Version: 8.0.0
Date: Tue Jan 28 2025
Ggps1
Mus musculusMGI:1341724
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ggps1

Species
Mus musculus
Symbol
Ggps1
Name
geranylgeranyl diphosphate synthase 1
Synonyms
  • 1810026C22Rik
  • 9530089B04Rik
Biotype
protein coding gene
Automated Description
Enables geranyltranstransferase activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Is expressed in aorta; brain; heart; liver; and lung. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1).
MGI Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12001
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensGGPS110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusGgps19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisggps15 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio rerioggps110 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogasterqm9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Saccharomyces cerevisiaeBTS19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Pdss1126240203 of 9☑☐☐☐☐☐☑☑☐ 
Pdss2212843233 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal coat/ hair morphology
abnormal lens morphology
abnormal retina blood vessel morphology
abnormal vitreous body morphology
cataract
impaired glucose tolerance
increased circulating cholesterol level
increased circulating glucose level
increased circulating HDL cholesterol level
increased leukocyte cell number
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Ggps1em2Cya
    • Ggps1em1flox
    		allele
    Ggps1em1Gpt
    • Ggps1em1Cflox
    		allele
    Ggps1tm1Licj
    • Ggppsfl
    		allele
    Ggps1em6Gpt
    • Ggps1em6Cd6001
    		allele
    Ggps1tm1b(EUCOMM)Wtsiallele
    		Yes
    Ggps1Gt(OST431024)Lex
    • Ggps1Gt(IRESBetageo)245Lex
    		allele
    Ggps1tm1a(EUCOMM)Wtsiallele
    NC_000079.7:g.14229964T>Cvariant
    SNP
    • intron variant
    NC_000079.7:g.14233016T>Cvariant
    SNP
    • intron variant
    NC_000079.7:g.14230570C>Avariant
    SNP
    • intron variant
    Showing 1 - 10 of 302 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Ggps1tm1b(EUCOMM)Wtsi/Ggps1+ [background:] C57BL/6N-Ggps1tm1b(EUCOMM)Wtsi/Ieg
    • abnormal coat/ hair morphology
    • abnormal lens morphology
    		MGI
    Ggps1tm1b(EUCOMM)Wtsi/Ggps1tm1b(EUCOMM)Wtsi [background:] C57BL/6N-Ggps1tm1b(EUCOMM)Wtsi/Ieg
    • preweaning lethality, complete penetrance
    		MGI
    Showing 1 - 2 of 2 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    2 interactor genes based on 2 annotations
    Ggps1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    RNA
    		UnkMus musculus
    protein
    • affinity chromatography technology
    		PMID:25737280
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    Genetic Interactions

    Ggps1 role
    Ggps1 genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    unspecified role
    		Fitm2Mus musculus
    unspecified role
    positive genetic interaction (sensu BioGRID)
    • increased cell proliferation
    		PMID:32968282
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