Version: 8.0.0
Date: Tue Jan 28 2025
Asap1
Mus musculusMGI:1342335
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Asap1

Species
Mus musculus
Symbol
Asap1
Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms
  • AV239055
  • Ddef1
Biotype
protein coding gene
Automated Description
Enables GTPase activator activity and phospholipid binding activity. Involved in regulation of postsynapse organization. Acts upstream of or within negative regulation of dendritic spine development and positive regulation of membrane tubulation. Located in dendritic spine and podosome. Is active in glutamatergic synapse. Is expressed in several structures, including gonad; hemolymphoid system; limb; long bone; and nervous system. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1).
MGI Description
PHENOTYPE: Homozygotes for a gene trapped allele show perinatal lethality, reduced respiratory rate, fetal growth retardation, slow weight gain, delayed bone ossification, reduced adipogenesis and altered in vitro differentiation of mesenchymal progenitor cells into chondrocytes, adipocytes and osteoblasts. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45854
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Asap1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Asap1 role
            Asap1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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