Gene

Klf3

Species
Mus musculus
Symbol
Klf3
Name
Kruppel-like transcription factor 3 (basic)
Synonyms
  • 9930027G08Rik
  • AL024007
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Orthologous to human KLF3 (KLF transcription factor 3).
MGI Description
PHENOTYPE: Homozygous null mice display reduced viability, body size and white adipose tissue. Mice homozygous for a gene trap allele exhibit cardiac defects, reduced body size and abnormal red blood cells. Mice heterozygous for an ENU-induced allele exhibit lethality with heart defects. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23235
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Mus musculusTg(Cd19-Klf3)2Bii
Showing 1 - 1 of 1 rows
per page

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Klf3Gt(CH0516)Wtsi/Klf3Gt(CH0516)Wtsi [background:] involves: 129P2/OlaHsd * C57BL/6
  • abnormal blood flow velocity
  • abnormal heart left ventricle morphology
MGI
Klf3Gt(XS0187)Wtsi/Klf3Gt(XS0187)Wtsi [background:] involves: 129P2/OlaHsd * C57BL/6
  • aortic valve stenosis
  • decreased abdominal fat pad weight
MGI
Klf3m1Cmhd/Klf3+ [background:] involves: BALB/cJ * C3H/HeJ * C57BL/6J
  • abnormal blood flow velocity
MGI
Klf3m1Cmhd/Klf3+ [background:] involves: C3H/HeJ * C57BL/6J
  • abnormal aortic valve cusp morphology
  • abnormal ascending aorta morphology
MGI
Klf3m1Cmhd/Klf3m1Cmhd [background:] involves: C3H/HeJ * C57BL/6J
  • abnormal interventricular septum morphology
  • abnormal ventricle myocardium morphology
MGI
Klf3tm1(cre/ERT2)Pzg/Klf3+ [background:] involves: 129P2/OlaHsd * C57BL/6J
  • no abnormal phenotype detected
MGI
Klf3tm1Merc/Klf3tm1Merc [background:] FVB.129-Klf3tm1Merc
  • abnormal cell differentiation
  • abnormal epididymal fat pad morphology
MGI
Klf3tm1Merc/Klf3tm1Merc [background:] involves: 129
  • infertility
  • preweaning lethality, incomplete penetrance
MGI
Klf3tm1Merc/Klf3tm1Merc Klf8Gt(AD0101)Wtsi/Klf8+ [background:] involves: 129P2/OlaHsd * FVB/NJ
  • preweaning lethality, incomplete penetrance
MGI
Klf3tm1Merc/Klf3tm1Merc Klf8Gt(AD0101)Wtsi/Klf8Gt(AD0101)Wtsi [background:] involves: 129P2/OlaHsd * FVB/NJ
  • embryonic lethality during organogenesis, incomplete penetrance
  • lethality during fetal growth through weaning, complete penetrance
MGI
Showing 1 - 10 of 13 rows
per page

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
64.965M64.970M64.975M64.980M64.985M64.990M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions

No data available