Gene

Actl7b

Species
Mus musculus
Symbol
Actl7b
Name
actin-like 7b
Synonyms
  • ENSMUSG00000070980
  • predicted gene, ENSMUSG00000070980
Biotype
protein coding gene
Automated Description
Located in cytoplasm. Is expressed in male reproductive gland or organ and small intestine. Orthologous to human ACTL7B (actin like 7B).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male sterility associated with severe and variable oligoasthenoteratozoospermia and multiple morphological abnormalities of the flagellum and sperm head. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11937
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal heart morphology
abnormal outer dense fiber morphology
abnormal seminiferous tubule epithelium morphology
abnormal sperm annulus morphology
abnormal sperm connecting piece morphology
abnormal sperm flagellum morphology
abnormal sperm head morphology
abnormal sperm midpiece morphology
abnormal sperm mitochondrial sheath morphology
abnormal sperm nucleus morphology
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Actl7btm1(KOMP)Vlcg/Actl7btm1(KOMP)Vlcg [background:] C57BL/6N-Actl7btm1(KOMP)Vlcg
  • abnormal outer dense fiber morphology
  • abnormal seminiferous tubule epithelium morphology
MGI
Actl7btm1.1(KOMP)Vlcg/Actl7btm1.1(KOMP)Vlcg [background:] C57BL/6N-Actl7btm1.1(KOMP)Vlcg/Tcp
  • abnormal heart morphology
  • abnormal urinary bladder morphology
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
56.7402M56.7404M56.7406M56.7408M56.7410M56.7412M56.7414M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions