Gene

Pdk2

Species
Mus musculus
Symbol
Pdk2
Name
pyruvate dehydrogenase kinase, isoenzyme 2
Synonyms
None
Biotype
protein coding gene
Automated Description
Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including glucose homeostasis; insulin receptor signaling pathway; and regulation of small molecule metabolic process. Acts upstream of or within regulation of calcium-mediated signaling. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Is expressed in aorta; cerebral cortex; cerebral cortex subventricular zone; heart; and liver. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased muscle contractile force. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11947
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
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      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            94.918M94.920M94.922M94.924M94.926M94.928M94.930M94.932M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Pdk2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Pdk2 role
              Pdk2 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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