Gene

Msh6

Species
Mus musculus
Symbol
Msh6
Name
mutS homolog 6
Synonyms
  • AU044881
  • AW550279
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and damaged DNA binding activity. Contributes to guanine/thymine mispair binding activity. Acts upstream of or within several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Located in chromatin. Part of MutSalpha complex. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Orthologous to human MSH6 (mutS homolog 6).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit premature death and are predisposed to tumor formation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11361
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
88.284M88.286M88.288M88.290M88.292M88.294M88.296M88.298M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions