Predicted to enable metal ion binding activity. Acts upstream of or within apoptotic signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and spleen. Used to study myelodysplastic/myeloproliferative neoplasm. Orthologous to human DIDO1 (death inducer-obliterator 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]