Gene

Creg1

Species
Mus musculus
Symbol
Creg1
Name
cellular repressor of E1A-stimulated genes 1
Synonyms
  • AA755314
  • Creg
Biotype
protein coding gene
Automated Description
Predicted to enable insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including endocytosis; lysosomal lumen acidification; and regulation of DNA-templated transcription. Located in endosome and lysosome. Part of transcription regulator complex. Is expressed in central nervous system; liver; and ureter. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1).
MGI Description
PHENOTYPE: Mice heterozygous for a knock-out allele exhibit decreased neovascularization after induction of hindlimb ischemia, and show increased infarction size, elevated cardiomyocyte apoptosis and impaired autophagy following myocardial ischemia/reperfusion injury. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13343
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            165.592M165.594M165.596M165.598M165.600M165.602M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Creg1 molecule type
            Interactor gene
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              Genetic Interactions

              Creg1 role
              Creg1 genetic perturbation
              Interactor gene
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