Enables signaling receptor binding activity. Involved in regulation of synapse pruning. Acts upstream of or within maintenance of synapse structure; motor learning; and neuron remodeling. Located in climbing fiber; cytoplasm; and presynapse. Is active in cerebellar climbing fiber to Purkinje cell synapse and synaptic cleft. Is expressed in several structures, including brain; genitourinary system; gut; liver; and lung. Orthologous to human C1QL1 (complement C1q like 1).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit impaired motor learning with alterned climbing fiber electrophysiology. [provided by MGI curators]