Gene

Creb3l1

Species
Mus musculus
Symbol
Creb3l1
Name
cAMP responsive element binding protein 3-like 1
Synonyms
  • BBF-2 (drosophila) homolog
  • MGC:25246
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and chromatin binding activity. Involved in several processes, including extracellular matrix constituent secretion; intracellular signal transduction; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within regulation of ossification. Located in endoplasmic reticulum. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal growth retardation, fragile skeleton, and decreased bone density, cortical and trabecular thickness, and osteoblast maturation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46004
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            91.815M91.820M91.825M91.830M91.835M91.840M91.845M91.850M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Creb3l1 molecule type
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              Genetic Interactions

              Creb3l1 role
              Creb3l1 genetic perturbation
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