Version: 8.0.0
Date: Tue Jan 28 2025
Creb3l1
Mus musculusMGI:1347062
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Creb3l1

Species
Mus musculus
Symbol
Creb3l1
Name
cAMP responsive element binding protein 3-like 1
Synonyms
  • BBF-2 (drosophila) homolog
  • MGC:25246
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and chromatin binding activity. Involved in several processes, including extracellular matrix constituent secretion; intracellular signal transduction; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within regulation of ossification. Located in endoplasmic reticulum. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal growth retardation, fragile skeleton, and decreased bone density, cortical and trabecular thickness, and osteoblast maturation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46004
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Creb3l1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Creb3l1 role
            Creb3l1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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