Enables P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within several processes, including flagellated sperm motility; sodium ion transport; and spermatogenesis. Predicted to be located in rod photoreceptor outer segment and sperm midpiece. Predicted to be part of sodium:potassium-exchanging ATPase complex. Predicted to be active in cell projection and plasma membrane. Is expressed in choroid plexus; epididymis; and testis. Orthologous to human ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4).
MGI Description
PHENOTYPE: Male mice homozygous for a knock-out allele exhibit infertility associated with asthenozoospermia and teratozoospermia. [provided by MGI curators]