Version: 8.0.0
Date: Tue Jan 28 2025
Grm6
Mus musculusMGI:1351343
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Grm6

Species
Mus musculus
Symbol
Grm6
Name
glutamate receptor, metabotropic 6
Synonyms
  • BC021919
  • cDNA sequence BC021919
Biotype
protein coding gene
Automated Description
Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity and protein homodimerization activity. Involved in locomotory behavior and sensory perception of light stimulus. Acts upstream of or within several processes, including retina development in camera-type eye; signal transduction; and synapse assembly. Located in new growing cell tip. Is active in cell tip and dendrite. Is expressed in prostate gland; retina inner nuclear layer; and testis. Used to study congenital stationary night blindness 1B. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6).
MGI Description
PHENOTYPE: Homozygous null mice show loss of ON responses without significant alteration of OFF responses in visual transmission or changes in visual behavioral responses. ENU-induced mutant mice have an ERG that lacks the rod b-wave and scotopic threshold response, while the cone ERG is of large amplitude. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24060
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Grm6 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Grm6 role
            Grm6 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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