Version: 8.0.0
Date: Tue Jan 28 2025
Sh2d2a
Mus musculusMGI:1351596
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Sh2d2a

Species
Mus musculus
Symbol
Sh2d2a
Name
SH2 domain containing 2A
Synonyms
  • Lad
  • Lck-associated adapter protein
Biotype
protein coding gene
Automated Description
Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within T cell proliferation. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis and multiple sclerosis. Orthologous to human SH2D2A (SH2 domain containing 2A).
MGI Description
PHENOTYPE: While T cell development is normal, T cell proliferation in response to TCR-mediated activation is impaired in homozygous null mice. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14388
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSH2D2A10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusSh2d2a9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriosi:ch73-109i22.25 of 10YesYes☐ ☐☐☐☑☑☑☑☑ ☐
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
decreased interferon-gamma secretion
decreased interleukin-2 secretion
decreased T cell proliferation
increased interleukin-4 secretion
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Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

          Transcript: Mode:

          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Sh2d2a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Sh2d2a role
            Sh2d2a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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