Gene

Zfp385a

Species
Mus musculus
Symbol
Zfp385a
Name
zinc finger protein 385A
Synonyms
  • Hzf
  • Zfp385
Biotype
protein coding gene
Automated Description
Enables mRNA 3'-UTR binding activity. Involved in DNA damage response and apoptotic process. Acts upstream of or within several processes, including myeloid cell differentiation; platelet alpha granule organization; and post-transcriptional regulation of gene expression. Located in dendrite and neuronal cell body. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human ZNF385A (zinc finger protein 385A).
MGI Description
PHENOTYPE: Homozygous null mice display partial postnatal lethality with gastrointestinal and intracranial hemorrhages, abnormal megakaryocyte development, and reduced body size. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23067
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Zfp385b149450403 of 9 
Zfp385c253143353 of 9 
Zmat3335232222 of 9 
Zfp346432636212 of 9 
Zmat1526935182 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal blood coagulation
abnormal megakaryocyte morphology
abnormal platelet morphology
decreased body size
decreased platelet alpha-granule number
gastrointestinal hemorrhage
intracranial hemorrhage
no abnormal phenotype detected
postnatal lethality, incomplete penetrance
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Zfp385aGt(PT1-ATG)1Ber
  • Hzf-
allele
Yes
Zfp385atm1Ber
  • Hzf-
allele
Yes
NC_000081.7:g.103225639T>Avariant
SNP
  • intron variant
NC_000081.7:g.103229273C>Tvariant
SNP
  • intron variant
NC_000081.7:g.103229975T>Cvariant
SNP
  • intron variant
NC_000081.7:g.103232094A>Gvariant
SNP
  • intron variant
NC_000081.7:g.103222574T>Cvariant
SNP
  • 3 prime UTR variant
NC_000081.7:g.103224722G>Avariant
SNP
  • intron variant
NC_000081.7:g.103227488A>Cvariant
SNP
  • intron variant
NC_000081.7:g.103230840C>Tvariant
SNP
  • intron variant
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Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
103.225M103.230M103.235M103.240M103.245MENSMUST00000168828 (Zfp385a)ENSMUST00000229373 (Zfp385a)ENSMUST00000229551 (Zfp385a)NM_001356627.2 (Zfp385a)NM_001411887.1 (Zfp385a)NM_001411888.1 (Zfp385a)NM_001411889.1 (Zfp385a)NM_013866.3 (Zfp385a)XM_006521053.4 (Zfp385a)XM_006521054.5 (Zfp385a)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
Zfp385a molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Otx2Mus musculus
protein
  • affinity chromatography technology
PMID:26426291
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Genetic Interactions

No data available