Gene

Arhgef1

Species
Mus musculus
Symbol
Arhgef1
Name
Rho guanine nucleotide exchange factor 1
Synonyms
  • Lbcl2
  • Lsc
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and microtubule depolymerization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and telencephalon. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in impaired humeral immunity, reduced numbers of marginal zone B (MZB) cells, decreased basal T cell proliferation, and reduced basal motility of lymphocytes but enhanced migration of MZB cells after serum activation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45872
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
24.604M24.606M24.608M24.610M24.612M24.614M24.616M24.618M24.620M24.622M24.624M24.626M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions