Version: 8.0.0
Date: Tue Jan 28 2025
Mapk8ip3
Mus musculusMGI:1353598
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Mapk8ip3

Species
Mus musculus
Symbol
Mapk8ip3
Name
mitogen-activated protein kinase 8 interacting protein 3
Synonyms
  • BB120594
  • c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1
Biotype
protein coding gene
Automated Description
Enables MAP-kinase scaffold activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of neuron migration; and regulation of MAPK cascade. Acts upstream of or within several processes, including JNK cascade; lung development; and nervous system development. Located in several cellular components, including Golgi membrane; axolemma; and smooth endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; pancreas; retina; and spleen. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13886
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Mapk8ip3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Mapk8ip3 role
            Mapk8ip3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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