Version: 8.0.0Date: Tue Jan 28 2025
Gene
Rnf19a
- Species
- Mus musculus
- Symbol
- Rnf19a
- Name
- ring finger protein 19A
- Synonyms
- AA032313
- Dorfin
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Is active in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Orthologous to human RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase).
- MGI Description
- PHENOTYPE: Mice homozygous for a gene-trapped allele exhibit decreased adult neurogenesis and enhanced long-term potentiation in the hippocampal dentate gyrus region, hyperactivity in a familiar environment, and a specific deficit in contextual fear conditioning, but not in other types of learning and memory. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11685
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- Chr15:36240080...36283293 - (43.21 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction