Gene

Lats2

Species
Mus musculus
Symbol
Lats2
Name
large tumor suppressor 2
Synonyms
  • 4932411G09Rik
  • AV277261
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of signal transduction. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2).
MGI Description
PHENOTYPE: Homozygous null mice display embryonic lethality with decreased cell proliferation, chromosomal instability, atrial hyperplasia, ventricular hypoplasia, delayed embryonic development, an irregular kinked neural tube, and hemorrhages. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24356
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensLATS210 of 10YesYes  
Rattus norvegicusLats29 of 9YesYes   
Xenopus tropicalislats29 of 9YesYes   
Danio reriolats210 of 10YesYes  
Drosophila melanogasterwts6 of 9YesNo   
Caenorhabditis eleganswts-16 of 9YesYes   
Caenorhabditis elegansT24D5.43 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal cell nucleus morphology
abnormal cell proliferation
abnormal centrosome morphology
abnormal fourth ventricle morphology
abnormal heart atrium morphology
abnormal intracellular organelle morphology
abnormal mitosis
abnormal pharyngeal arch morphology
abnormal spinal cord morphology
abnormal startle reflex
Showing 1 - 10 of 27 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Lats1tm1Noj/Lats1tm1Noj Lats2tm1.1Dupa/Lats2tm1.1Dupa [background:] involves: 129P2/OlaHsd * 129S2/SvPas
  • abnormal bile duct epithelium morphology
  • enlarged liver
MGI
Lats1tm1Noj/Lats1tm1Noj Lats2tm1.1Dupa/Lats2tm1.1Dupa Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Yap1tm1.1Dupa/Yap1tm1.1Dupa [background:] involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas
  • abnormal bile duct epithelium morphology
  • enlarged liver
MGI
Lats2tm1.1Dupa/Lats2tm1.1Dupa [background:] involves: 129P2/OlaHsd
  • no abnormal phenotype detected
MGI
Lats2tm1.1Jfm/Lats2tm1.1Jfm [background:] involves: 129S6/SvEvTac * C57BL/6Brd * CD-1
  • no abnormal phenotype detected
MGI
Lats2tm1Dgen/Lats2+ [background:] involves: 129P2/OlaHsd * C57BL/6
  • abnormal startle reflex
MGI
Lats2tm1Dgen/Lats2tm1Dgen [background:] involves: 129P2/OlaHsd * C57BL/6
  • embryonic lethality during organogenesis, complete penetrance
MGI
Lats2tm1Noj/Lats2+ [background:] involves: 129S2/SvPas * C57BL/6
  • prenatal lethality, complete penetrance
MGI
Lats2tm1Noj/Lats2tm1Noj [background:] involves: 129S2/SvPas
  • abnormal centrosome morphology
MGI
Lats2tm1Noj/Lats2tm1Noj [background:] involves: 129S2/SvPas * C57BL/6
  • abnormal cell nucleus morphology
  • abnormal fourth ventricle morphology
MGI
Lats2tm1Raz/Lats2tm1Raz [background:] involves: 129P2/OlaHsd * C57BL/6
  • abnormal cell proliferation
  • abnormal heart atrium morphology
MGI
Showing 1 - 10 of 10 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
57.930M57.935M57.940M57.945M57.950M57.955M57.960M57.965M57.970M57.975M57.980M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 3 annotations
Lats2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CitMus musculus
protein
  • imaging technique
PMID:30865227
RNA
HnrnpdMus musculus
protein
  • affinity chromatography technology
PMID:30418981
protein
YAP1Homo sapiens
protein
  • protein kinase assay
PMID:22863277
Showing 1 - 3 of 3 rows
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Genetic Interactions

No data available