Gene

Cdc20

Species
Mus musculus
Symbol
Cdc20
Name
cell division cycle 20
Synonyms
  • 2310042N09Rik
  • C87100
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including anaphase-promoting complex binding activity; histone deacetylase binding activity; and ubiquitin ligase activator activity. Involved in metaphase/anaphase transition of meiosis I; positive regulation of synapse maturation; and positive regulation of synaptic plasticity. Acts upstream of or within mitotic sister chromatid cohesion; mitotic spindle assembly; and regulation of meiotic nuclear division. Located in centrosome and kinetochore. Is expressed in several structures, including brain; early conceptus; female reproductive system; hemolymphoid system; and trigeminal ganglion. Orthologous to human CDC20 (cell division cycle 20).
MGI Description
PHENOTYPE: Mice homozygous for mutations in this gene display embryonic lethality with cell cycle abnormalities. Mice heterozygous for a mutation in this gene display increased tumor incidence and increased incidence of aneuploidy. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19918
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
118.2905M118.2910M118.2915M118.2920M118.2925M118.2930M118.2935M118.2940M118.2945M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions