Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence. [provided by MGI curators]