ubiquitin protein ligase E3 component n-recognin 3
Synonyms
1110059H15Rik
4833421P10Rik
Biotype
protein coding gene
Automated Description
Enables ubiquitin protein ligase activity. Involved in several processes, including sensory perception of smell; suckling behavior; and ubiquitin-dependent protein catabolic process. Acts upstream of or within in utero embryonic development and olfactory behavior. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion and dorsal root ganglion. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3).
MGI Description
PHENOTYPE: Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia. [provided by MGI curators]