Gene

Ubr3

Species
Mus musculus
Symbol
Ubr3
Name
ubiquitin protein ligase E3 component n-recognin 3
Synonyms
  • 1110059H15Rik
  • 4833421P10Rik
Biotype
protein coding gene
Automated Description
Enables ubiquitin protein ligase activity. Involved in several processes, including sensory perception of smell; suckling behavior; and ubiquitin-dependent protein catabolic process. Acts upstream of or within in utero embryonic development and olfactory behavior. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion and dorsal root ganglion. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3).
MGI Description
PHENOTYPE: Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21497
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
69.74M69.76M69.78M69.80M69.82M69.84M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions