Gene

Tob2

Species
Mus musculus
Symbol
Tob2
Name
transducer of ERBB2, 2
Synonyms
  • 2900090N22Rik
  • 4930545K18Rik
Biotype
protein coding gene
Automated Description
Enables nuclear vitamin D receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation; positive regulation of ossification; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Meckel's cartilage; cerebral cortex; genitourinary system; lens; and orbito-sphenoid. Orthologous to human TOB2 (transducer of ERBB2, 2).
MGI Description
PHENOTYPE: Mice homozygous for a targeted mutation display reduced bone mass due to increased osteoclast numbers and acceleration of the bone resorption rate. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR17537
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Tob1140263528 of 9 
Btg1b217055362 of 9 
Btg1315657382 of 9 
Btg1c412562422 of 9 
Btg2511262412 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Tob2tm1Tya/Tob2tm1Tya [background:] involves: 129S4/SvJae * C57BL/6
  • abnormal osteoclast differentiation
  • abnormal osteoclast physiology
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
81.733M81.734M81.735M81.736M81.737M81.738M81.739M81.740M81.741M81.742M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 3 annotations
Tob2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ctnnb2Danio rerio
protein
  • affinity chromatography technology
PMID:16890162
protein
smad3bDanio rerio
protein
  • affinity chromatography technology
PMID:16890162
protein
VdrMus musculus
protein
  • pull down
PMID:18358842
Showing 1 - 3 of 3 rows
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Genetic Interactions

No data available