Version: 8.0.0Date: Tue Jan 28 2025
Gene
Tbc1d1
- Species
- Mus musculus
- Symbol
- Tbc1d1
- Name
- TBC1 domain family, member 1
- Synonyms
- 1110062G02Rik
- AI385682
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adrenal medulla; brain; genitourinary system; gut gland; and retina. Orthologous to human TBC1D1 (TBC1 domain family member 1).
- MGI Description
- PHENOTYPE: Mice homozgyous for a targeted mutation that removes exon 4 exhibit no adverse phenotype. Mice homozygous for a gene trap allele exhibit decreased body weight, resistance to diet-induced obesity, increased fat oxidization and decreased glucose uptake in the muscle. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR22957
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|
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Sequence Feature Viewer
- Genome location
- Chr5:64313648...64508829 + (195.18 kb)
- Assembly version
- GRCm39
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